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REDE GOIANA DE PESQUISA EM TUBERCULOSE

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Programa de Pós Graduação em Medicina Tropical e Saúde Pública
tuberculosis

Artigo novo do grupo: Non-classical circulating monocytes in severe obesity and obesity with uncontrolled diabetes: A comparison with tuberculosis and healthy individuals

Por Ana Paula Junqueira Kipnis. Criada em 06/12/18 07:38. Atualizada em 06/12/18 07:42.

O grupo publicou um trabalho realizado pelo doutorando Danilo Pires de Resende e a Dra. Adeliane Castro da Costa em revista internacional, Qualis A da CAPES por ser a revista com maior número de citações na área de tuberculose.

Este trabalho mostra pela primeira vez a comparação entre os monócitos de pessoas obesas com monócitos de pacientes com tuberculose. Neste trabalho observamos que os monæocitos apresentam várias semelhanças e incapacidade de controlar o crescimento de Mycobacterium tuberculosis, o agente causal da tuberculose, o que pode indicar um dos motivos para a maior susceptibilidade para a tuberculose das pessoas obesas com diabetes.

Os estudos continuam para desvendar estas relações. Convidamos a todos a lerem o resumo e ler a publicação.

 

 

https://doi.org/10.1016/j.tube.2018.11.003

Severe obesity and diabetes lead to a significant decrease in quality of life. Although controversial, populationwide
studies have implicated obesity in the development of tuberculosis (TB). Non-classical monocytes have
been described in obesity and TB, whereas in diabetes they have been associated with poorer clinical outcomes.
The present study focuses on the functional significance of several monocyte populations of obese, obesityrelated
diabetic (OBDM), non-obese/diabetic tuberculosis and non-obese healthy control patients. Monocytes
were evaluated by measuring expression of CD86, CD206, TLR-2 and TLR-4 as well as production of IL-6, IL-12,
and by using a mycobacterial growth inhibition assay for both Mycobacterium tuberculosis and M. abscessus subsp.
massiliense. Non-classical monocytes from OBDM and non-obese TB patients exhibited similar activation profiles
(CD86/CD206/TLR-2 and TLR-4 expressions). Only monocytes from TB patients had a higher positivity for IL-12
and IL-6, whereas adiponectin serum levels increased similarly between TB and OBDM patients. Monocytes from
active TB patients and OBDM were more permissive to Mtb growth than obese individuals, but this susceptibility
was not observed for M. abscessus subsp. massiliense. From these findings, we conclude that diabetes and tuberculosis
had similarities in the population of circulating non-classical monocytes, improving our understanding