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REDE GOIANA DE PESQUISA EM TUBERCULOSE

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Programa de Pós Graduação em Medicina Tropical e Saúde Pública

  • Ana Paula e André

    Ana Paula e André

  • Chaos To Order

    Chaos To Order

  • RGPTB n o 11º Congresso Brasileiro de Saúde Coletiva/ABRASCÃO - 2015

    RGPTB n o 11º Congresso Brasileiro de Saúde Coletiva/ABRASCÃO - 2015

  • festa de final de ano 2016

    festa de final de ano 2016

  • componentes

    componentes

  • sbm 2015

    sbm 2015

  • IC no Conpeex

    IC no Conpeex

  • slamtb

    slamtb

  • foto comemorativa dos 50 anos da Escola de Veterinária

    foto comemorativa dos 50 anos da Escola de Veterinária

  • premiação PIBIC 2013 Joseane Damasceno Rosa

    premiação PIBIC 2013 Joseane Damasceno Rosa

  • Baile UFG 2013

    Baile UFG 2013

  • SBI 2016

    SBI 2016

  • Palestra em Mesa redonda SBI 2016

    Palestra em Mesa redonda SBI 2016

  • Workshop da Rede Pró Centro-Oeste de Pesquisa Inovatoxin, realizado no dia 24 de novembro de 2017.

    Apresentações:

    Atividade de um peptídeo antimicrobiano de escorpião contra biofilme de Acinetobacter Baumannii multidroga resistente”- Rogério Coutinho das Neves

    Prospecção de compostos isolados e fracionados de plantas do cerrado e pantanal com atividade anti-bacteriana” - Rayanny Gomes de Andrade

    Solução Florida- Ipê amarelo como antidoto para picada de cobra - Iluska Senna Bonfá Moslaves

    Peptídeo derivado do veneno do escorpião Hadrurus gertschi inibe o crescimento de Mycobacterium abscessus subsp. massiliense - Monalisa Martins Trentini

    Peptídeos bioinspirados da peçonha de vespas para o tratamento da Doença de Parkinson e da Epilepsia - Márcia Renata Mortari 

  • DPOC

    Artigos 2017: Do COPD and Healthy Subjects have Similar Acute Inflammatory Response Induced by Sub-maximum Effort Test?

    Autores: Krislainy De Sousa Corrêa , Adeliane Castro Da Costa , Ana Paula Perillo Ferreira Carvalho , José Laerte Rodrigues Da Silva Júnior , Maria Rosedália De Moraes , Ana Paula Junqueira-Kipnis and Marcelo Fouad Rabahi

    Abstract

    Introduction: COPD (chronic obstructive pulmonary disease) presents a low degree of systemic inflammation responsible for the disease’s extra pulmonary consequences. Its inflammatory profile can be altered by acute exercise. However, acute effects of a sub maximum test, capable of reproducing activities of daily living (ADL) in sedentary COPD individuals, are not well-known

    Objective: To evaluate if the six-minute walk test (6MWT) is capable of altering interleukin-6 (IL-6) blood levels, tumoral necrosis factor alfa (TNF-α) and hypersensitive C reactive protein (hs-CRP) in relation to the basal level of COPD individuals.

    Methods: 21 individuals with moderate and severe COPD and 8 healthy individuals, with no history of smoking, sedentary, matched by age were assessed regarding plasma levels of IL-6, TNF-α and hs-CRP before and right after a 6MWT. They also did spirometry and body composition analysis.

    Results: 6MWT did not provoke significant alteration in IL-6 levels in COPD individuals (pre=4.53 ± 9.0 pg/ml vs. post=7.14 ± 11.31 pg/ml, p=0.11), whereas in healthy individuals this increase was significant (pre=1.56 ± 6.45 pg/ml vs. post=4.37 ± 8.0 pg/ml, p<0.01). COPD individuals present higher hs-CRP blood levels when compared to healthy subjects both in rest (8.15 ± 9.68 pg/ml vs. 2.60 ± 1.88 pg/ml, p=0.02), and after exercise (8.18 ± 9.08 pg/ml vs. 2.62 ± 1.85 pg/ml, p=0.02. TNF-α did not present difference between groups during rest (COPD=2.13 ± 1.03 pg/ml vs. healthy=2.00 ± 0.59 pg/ml, p>0.05) as well as after 6MWT (COPD=2.48 ± 1.92 pg/ml vs. healthy=1.89 ± 0.69 pg/ml, p>0.05), and their intragroup focus was not affected by the effort (p>0.05).

    Conclusions: In COPD patients, 6MWT does not induce acute inflammatory response of IL-6 at the same proportion of that of healthy subjects. Hs-CRP’s and TNFα’s response to 6MWT was similar between groups. COPD patients presented higher concentrations of hs-CRP than healthy individuals.

     

    O texto completo pode ser encontrado no link:

    https://www.omicsonline.org/open-access/do-copd-and-healthy-subjects-have-similar-acute-inflammatory-responseinduced-by-submaximum-effort-test.php?aid=87058

  • Eduardo CMX

    Artigos 2017: Identification of specific antibodies against the Ag85C-MPT51-HspX fusion protein (CMX) for serological screening of tuberculosis in endemic area.

    Autores: Zagmignan ACosta ACDViana JLLima Neto LGMonteiro CAGaioso Neto AGJunqueira-Kipnis APde Sousa EM.

    Abstract

    OBJECTIVES:

    Development of new tools for rapid and accurate diagnosis of tuberculosis (TB) is considered a strategy for controlling the disease. The recombinant CMX fusion protein is composed of immunodominant epitopes of the Ag85C (Rv0129c), MPT51 (Rv3803c) and the entire HspX (Rv2031c) proteins from Mycobacterium tuberculosis H37Rv (Mtb). The aim of this study was to evaluate the applicability of a test using the CMX protein in individuals suspected of TB.

    METHODS:

    Indirect ELISA was used to measure serum anti-CMX IgM and IgG in individuals with pulmonary TB.

    RESULTS:

    Patients with pulmonary TB had higher titers of IgM (OD = 0.502 ± 0.281) than healthy controls (OD = 0.200 ± 0.125). The cutoff for IgM-ELISA was determined using ROC curve analyzes (AUC = 0.868) with a sensitivity of 80.1% and a specificity of 78.2%. Patients with pulmonary TB also had higher titers of IgG (OD = 0.525 ± 0.391) than healthy controls (OD = 0.215 ± 0.077). The cutoff for IgG-ELISA was determined using ROC curve analyzes (AUC = 0.864) with a sensitivity of 81.7% and a specificity of 74.7%.

    CONCLUSION:

    The results suggest that the recombinant protein CMX can be used in a serological test to complement the screening of individuals suspected of having active pulmonary TB.

     

    O artigo completo pode ser encontrado no link:

    http://www.tandfonline.com/doi/abs/10.1080/1744666X.2017.1345626?journalCode=ierm20